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High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded Doppler continuous monitoring without thrombolytic drug.

Authors :
Cintas P
Le Traon AP
Larrue V
Source :
Stroke [Stroke] 2002 Feb; Vol. 33 (2), pp. 626-8.
Publication Year :
2002

Abstract

Background and Purpose: Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion.<br />Methods: We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator.<br />Results: Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2+/-9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2+/-4.1 at baseline, 19.2+/-5 at 2 hours, and 15.6+/-3.4 at 24 hours (P=0.1).<br />Conclusions: In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.

Details

Language :
English
ISSN :
1524-4628
Volume :
33
Issue :
2
Database :
MEDLINE
Journal :
Stroke
Publication Type :
Academic Journal
Accession number :
11823681
Full Text :
https://doi.org/10.1161/hs0202.103073