Back to Search
Start Over
Mechanism of inhibition of small intestinal motility by restraint stress differs from that with norepinephrine treatment in rats.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2002 Jan; Vol. 25 (1), pp. 122-4. - Publication Year :
- 2002
-
Abstract
- We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic beta3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using alpha- and beta-adrenergic antagonists. SR59230A did not recover the norepinephrine-induced inhibition of small intestinal motility. The norepinephrine-induced inhibition of small intestinal motility was recovered after administration of the alpha2-antagonist yohimbine, but not by alpha1-, beta1-, and beta2-antagonists. Considering these results, it is reasonable to assume that the mechanisms of inhibition of small intestinal motility due to restraint stress and norepinephrine treatment are different.
- Subjects :
- Adrenergic alpha-1 Receptor Antagonists
Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-Antagonists pharmacology
Adrenergic beta-2 Receptor Antagonists
Animals
Male
Rats
Rats, Wistar
Restraint, Physical
Adrenergic alpha-Agonists pharmacology
Gastrointestinal Motility physiology
Intestine, Small physiopathology
Norepinephrine pharmacology
Stress, Psychological physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 11824540
- Full Text :
- https://doi.org/10.1248/bpb.25.122