[Expression of oncogene ras product p21 protein in the tissues of penis cancer and its surrounding tissues].

Objective: To explore the clinical significance of expression of oncogene ras product p21 protein in the tissues of penis cancer and its surrounding tissues.
Method: Oncogene ras product p21 protein in 32 cases of penis cancer, 32 cases of para-carcinoma tissues and in 16 cases of normal penis tissues were detected by immunohistochemical ABC method.
Result: p21 protein expressed in 28 cases of penis cancer and 8 cases of para-carcinoma tissues, but it did not express in 16 cases of normal penis. Expression of p21 protein was related to pathological grading and clinical stage i. e, expression of p21 protein enhanced with the increasing of grading and stage. The positive cases of p21 protein expression in para-carcinoma tissue had worse impact on the prognosis of early recurrence and metastasis.
Conclusion: p21 protein could be used as predictor of malignant potential and prognosis of penis cancer.