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Valacyclovir prophylaxis for the prevention of Herpes simplex virus reactivation in recipients of progenitor cells transplantation.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 2002 Feb; Vol. 29 (3), pp. 263-7. - Publication Year :
- 2002
-
Abstract
- HSV can cause oral lesions that exacerbate chemotherapy-related mucositis. Intravenous acyclovir is effective in preventing HSV reactivations, but expensive. Valacyclovir has good bioavailability and has not been studied for prophylaxis of HSV among PCT patients. We compared the efficacy and costs of valacyclovir in preventing HSV reactivation among HSV seropositive autologous progenitor cell transplantation (APCT) patients with historical controls in whom intravenous acyclovir or no HSV prophylaxis were used. Valacyclovir group: From October 1997 to April 1999 108 adult patients received valacyclovir 500 mg twice daily from day -3 of APCT until neutropenia recovery or day +30. Valacyclovir was switched to intravenous acyclovir in cases of oral intolerance (17 patients) or suspected HSV reactivation (five patients). Intravenous acyclovir group: From January 1996 to October 1997 43 patients received 5 mg/kg twice-daily intravenous acyclovir from day -3 until recovery from neutropenia. No prophylaxis group: 38 patients from January 1996 to October 1997 did not receive HSV prophylaxis. HSV reactivations were seen in 2.7%, 2% and 45% of patients in the valacyclovir, intravenous acyclovir, and no prophylaxis groups, respectively. Valacyclovir was well tolerated and was the least expensive strategy. Oral valacyclovir was as effective as intravenous acyclovir for the prophylaxis of HSV reactivation in APCT patients.
- Subjects :
- Acyclovir economics
Acyclovir standards
Adolescent
Adult
Aged
Antiviral Agents economics
Antiviral Agents standards
Costs and Cost Analysis
Female
Hematopoietic Stem Cell Transplantation methods
Herpes Simplex drug therapy
Humans
Male
Middle Aged
Simplexvirus growth & development
Transplantation, Autologous adverse effects
Transplantation, Autologous methods
Treatment Outcome
Valacyclovir
Valine economics
Valine standards
Virus Activation drug effects
Acyclovir administration & dosage
Acyclovir analogs & derivatives
Antiviral Agents administration & dosage
Hematopoietic Stem Cell Transplantation adverse effects
Herpes Simplex prevention & control
Simplexvirus drug effects
Valine administration & dosage
Valine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 11859400
- Full Text :
- https://doi.org/10.1038/sj.bmt.1703354