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Colorectal cancer in mice genetically deficient in the mucin Muc2.
- Source :
-
Science (New York, N.Y.) [Science] 2002 Mar 01; Vol. 295 (5560), pp. 1726-9. - Publication Year :
- 2002
-
Abstract
- The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.
- Subjects :
- Adenocarcinoma chemistry
Adenocarcinoma pathology
Adenoma chemistry
Adenoma pathology
Animals
Apoptosis
Cell Differentiation
Cell Division
Cell Lineage
Cell Movement
Colon chemistry
Colon cytology
Colon pathology
Colorectal Neoplasms metabolism
Colorectal Neoplasms pathology
Cytoskeletal Proteins analysis
Disease Progression
Duodenal Neoplasms chemistry
Duodenal Neoplasms pathology
Duodenum chemistry
Duodenum cytology
Duodenum pathology
Epithelial Cells chemistry
Epithelial Cells physiology
Female
Gene Targeting
Goblet Cells cytology
Intestinal Mucosa chemistry
Intestinal Mucosa cytology
Intestinal Mucosa pathology
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mucin-2
Mucins analysis
Proto-Oncogene Proteins c-myc analysis
beta Catenin
Colorectal Neoplasms etiology
Mucins genetics
Mucins physiology
Trans-Activators
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 295
- Issue :
- 5560
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 11872843
- Full Text :
- https://doi.org/10.1126/science.1069094