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Autocrine stimulation of cardiac Na(+)-Ca(2+) exchanger currents by endogenous endothelin released by angiotensin II.
- Source :
-
Circulation research [Circ Res] 2002 Mar 08; Vol. 90 (4), pp. 374-6. - Publication Year :
- 2002
-
Abstract
- The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na(+)-Ca(2+) exchanger (I(NCX)) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. I(NCX) was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased I(NCX) at potentials higher than 0 mV (at +60 mV: 2.07 +/- 0.22 pA/pF in control versus 2.73 +/- 0.22 pA/pF in Ang II, n=9; P<0.05). The increase in I(NCX) induced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 micromol/L) (at +60 mV: 2.15 +/- 0.27 pA/pF in control versus 2.01+/- 0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II on I(NCX) is the result of the autocrine actions of ET released by the octapeptide.
- Subjects :
- Angiotensin II pharmacology
Animals
Autocrine Communication drug effects
Cats
Endothelin Receptor Antagonists
In Vitro Techniques
Ion Transport drug effects
Ion Transport physiology
Membrane Potentials drug effects
Myocardium cytology
Patch-Clamp Techniques
Peptides, Cyclic pharmacology
Sodium-Calcium Exchanger antagonists & inhibitors
Thiourea pharmacology
Angiotensin II metabolism
Autocrine Communication physiology
Endothelins metabolism
Myocardium metabolism
Sodium-Calcium Exchanger metabolism
Thiourea analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4571
- Volume :
- 90
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Circulation research
- Publication Type :
- Academic Journal
- Accession number :
- 11884364
- Full Text :
- https://doi.org/10.1161/hh0402.105373