Back to Search
Start Over
Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease.
Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 2002 Feb; Vol. 29 (4), pp. 357-60. - Publication Year :
- 2002
-
Abstract
- Sclerodermoid chronic graft-versus-host disease (sGVHD) is a well-known complication in patients with a long history of chronic GVHD. Pulmonary involvement in chronic GVHD presents typically as bronchiolitis obliterans (BO). Pulmonary fibrosis after allogeneic hematopoietic stem cell transplantation (HSCT) is presumed to be caused by the long-term toxicity of the conditioning regimen or the result of lung injury elicited predominantly by viral infections or GVHD. We present two patients with late onset pulmonary fibrosis associated with moderate sGVHD of the skin after HSCT. At the initial diagnosis of chronic GVHD both patients presented with symptoms of interstitial pneumonia. Years later both patients developed moderate to severe interstitial pulmonary fibrosis in association with sGVHD. One patient showed additional clinical and histological signs of BO. While one patient responded to increased immunosuppression including total nodal irradiation (1 Gy), the other patient died due to complications related to pulmonary fibrosis.
- Subjects :
- Adult
Bone Marrow Transplantation adverse effects
Cryptogenic Organizing Pneumonia etiology
Female
Graft vs Host Disease pathology
Humans
Immunosuppression Therapy adverse effects
Leukemia, Myeloid, Acute therapy
Leukemia-Lymphoma, Adult T-Cell therapy
Male
Pulmonary Fibrosis pathology
Scleroderma, Systemic pathology
Skin Diseases etiology
Skin Diseases pathology
Transplantation Conditioning adverse effects
Graft vs Host Disease etiology
Pulmonary Fibrosis etiology
Scleroderma, Systemic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 11896434
- Full Text :
- https://doi.org/10.1038/sj.bmt.1703386