Back to Search
Start Over
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Apr 01; Vol. 168 (7), pp. 3376-86. - Publication Year :
- 2002
-
Abstract
- We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-1a lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well as reduced concentrations of serum IgM and IgA. The rac2(-/-) B lymphocytes exhibited reduced calcium flux following coligation of B cell AgR and CD19 and reduced chemotaxis in chemokine gradients. T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics, in rac2(-/-) mice, while T-dependent responses to nitrophenyl-keyhole limpet hemocyanin were subtly abnormal. Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo.
- Subjects :
- Actins antagonists & inhibitors
Actins metabolism
Animals
Antibody-Producing Cells pathology
Antigens, CD19 immunology
Antigens, CD19 metabolism
Antigens, T-Independent pharmacology
B-Lymphocyte Subsets pathology
Calcium antagonists & inhibitors
Calcium metabolism
Cell Differentiation genetics
Cell Differentiation immunology
Cell Migration Inhibition
Chemokines pharmacology
Down-Regulation genetics
Down-Regulation immunology
Haptens
Hemocyanins pharmacology
Immunoglobulin A blood
Immunoglobulin G biosynthesis
Immunoglobulin G blood
Immunoglobulin M blood
Ligands
Lymphocyte Activation genetics
Lymphopenia genetics
Lymphopenia immunology
Lymphopenia pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Antigen, B-Cell physiology
Up-Regulation genetics
Up-Regulation immunology
rac GTP-Binding Proteins deficiency
rac GTP-Binding Proteins genetics
RAC2 GTP-Binding Protein
B-Lymphocyte Subsets immunology
B-Lymphocyte Subsets metabolism
Chemotaxis, Leukocyte immunology
Receptors, Antigen, B-Cell metabolism
rac GTP-Binding Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 168
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 11907095
- Full Text :
- https://doi.org/10.4049/jimmunol.168.7.3376