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New thiazane and thiazolidine PNA monomers: synthesis, incorporation into PNAs and hybridization studies.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Apr 08; Vol. 12 (7), pp. 1047-50. - Publication Year :
- 2002
-
Abstract
- New constrained PNA monomers containing a substituted thiazolidine or a thiazane ring were synthesized and incorporated in the center of a 9-mer homothymine PNA. The PNA/DNA hybrids stability was studied by UV-melting experiments which showed that the presence of the modified unit destabilizes the PNA/DNA triplexes.
- Subjects :
- Nucleic Acid Conformation
Nucleic Acid Hybridization
RNA chemistry
RNA metabolism
Spectrophotometry
Stereoisomerism
Temperature
Thermodynamics
Thiazines metabolism
Thiazoles metabolism
DNA chemistry
Nucleic Acids chemistry
Peptide Nucleic Acids chemical synthesis
Peptide Nucleic Acids chemistry
Thiazines chemistry
Thiazoles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 12
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11909714
- Full Text :
- https://doi.org/10.1016/s0960-894x(02)00076-8