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Results of multimodality therapy for squamous cell carcinoma of maxillary sinus.
- Source :
-
Cancer [Cancer] 2002 Mar 01; Vol. 94 (5), pp. 1476-82. - Publication Year :
- 2002
-
Abstract
- Background: A wide variety of modalities, including surgery, radiation therapy, and chemotherapy, alone or in combination, have been used for the treatment of squamous cell carcinoma (SCC) of the maxillary sinus to obtain better local control and maintain functions. However, there is still much controversy with regard to the optimum treatment.<br />Methods: From 1987 to 1999, 33 patients with SCC of maxillary sinus were treated at the Department of Otolaryngology-Head and Neck Surgery, University of Tokyo Hospital. The treatment consisted of 30-40 grays (Gy) of preoperative radiotherapy with concomitant intraarterial infusion of 5-fluorouracil and cisplatin followed by surgery and 30-40 Gy of postoperative radiotherapy, for tumors without skull base invasion. For tumors invading the skull base, preoperative systemic chemotherapy with or without radiotherapy was performed, instead of intraarterial chemotherapy, then followed by skull base surgery. The surgical procedures varied according to the extent of tumor. Results were compared with those of the 108 patients treated in our hospital from 1976 to 1982.<br />Results: Partial maxillectomy was performed in 2 T2 patients and 12 T3 patients. Total maxillectomy was performed in 1 T2 patient, 3 T2 patients, and 7 T4 patients. Skull base surgery was performed in eight T4 patients. Orbital content and hard palate were preserved in 22 patients and 18 patients, respectively. The overall 5-year survival rates were 86% in T 3 patients and 67 % in T4 patients, respectively.<br />Conclusions: Our multimodal treatment has provided favorable local control and survival outcome with good functional results.<br /> (Copyright 2002 American Cancer Society.)
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell surgery
Cisplatin administration & dosage
Combined Modality Therapy
Female
Fluorouracil administration & dosage
Humans
Infusions, Intra-Arterial
Male
Maxillary Sinus Neoplasms surgery
Middle Aged
Neoadjuvant Therapy
Neoplasm Invasiveness
Retrospective Studies
Skull Neoplasms pathology
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Maxillary Sinus Neoplasms drug therapy
Maxillary Sinus Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 94
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 11920504
- Full Text :
- https://doi.org/10.1002/cncr.10253