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A surface-modified chylomicron remnant-like emulsion for percutaneous computed tomography lymphography: synthesis and preliminary imaging findings.
- Source :
-
Investigative radiology [Invest Radiol] 2002 Apr; Vol. 37 (4), pp. 232-9. - Publication Year :
- 2002
-
Abstract
- Rationale and Objectives: To assess a surface-modified emulsion as a percutaneous CT lymphographic agent in normal dogs.<br />Methods: An iodinated chylomicron remnant-like microemulsion was formulated with a mean particle size of 91.3 nm and an iodine concentration of 91 mg I/mL. Contrast material (2 mL) was injected into the subcutaneous tissues of the metatarsus and metacarpus of six normal dogs to enhance popliteal and cervical lymph nodes, respectively. CT images were acquired at 0, 15, 30, 45, 60, 240, 480, and 1440 minutes.<br />Results: Significant lymph node enhancement occurred in as little as 15 minutes after injection and persisted at least 8 hours. Node opacification was most pronounced at 1 to 4 hours postinjection and exceeded 200 HU in some nodes (precontrast attenuation = 45 HU). Marked enhancement of popliteal efferent lymphatics and of iliac and sacral node groups also occurred indicating distribution to second order nodes. Attenuation of enhanced nodes reverted to precontrast levels by 24 hours.<br />Conclusion: The new surface-modified, chylomicron remnant-like emulsion provided marked, selective enhancement of targeted lymph nodes after subcutaneous administration. Moreover, the formulation produced significant opacification of more distant node groups from a single injection.
- Subjects :
- Animals
Contrast Media pharmacokinetics
Dogs
Emulsions
Iopanoic Acid analogs & derivatives
Iopanoic Acid pharmacokinetics
Lipids pharmacokinetics
Lymphography instrumentation
Microscopy, Electron
Particle Size
Rats
Tomography, X-Ray Computed instrumentation
Contrast Media chemistry
Iodine pharmacokinetics
Iopanoic Acid chemistry
Lymph Nodes diagnostic imaging
Lymphography methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 0020-9996
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Investigative radiology
- Publication Type :
- Academic Journal
- Accession number :
- 11923646
- Full Text :
- https://doi.org/10.1097/00004424-200204000-00009