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[New treatment approaches in sepsis].
- Source :
-
Zentralblatt fur Chirurgie [Zentralbl Chir] 2002 Mar; Vol. 127 (3), pp. 174-9. - Publication Year :
- 2002
-
Abstract
- The treatment of sepsis consists of focus control as well as supportive and adjuvant therapy. Especially the last option has been investigated during the last years. Different approaches showed promising results in animal experiments and phase-I trials but did not prove to be successful in large multicenter studies. The application of TNF-receptors or interleukin-1 receptor antagonists did not lead to an improvement of outcome in patients with sepsis. Most studies with TNF-antibodies also presented negative results. However, a recent large study with a monoclonal antibody against TNFalpha demonstrated a significant survival benefit. The recently published PROWESS study is the first investigation demonstrating the decrease of mortality in patients with sepsis after administration of protein C. Additionally, current data support the low-dose hydrocortisone therapy in patients with vasopressor dependent septic shock.
- Subjects :
- Animals
Antibodies, Monoclonal therapeutic use
Humans
Hydrocortisone therapeutic use
Protein C therapeutic use
Receptors, Interleukin-1 antagonists & inhibitors
Receptors, Tumor Necrosis Factor antagonists & inhibitors
Systemic Inflammatory Response Syndrome mortality
Treatment Outcome
Anti-Inflammatory Agents therapeutic use
Systemic Inflammatory Response Syndrome therapy
Subjects
Details
- Language :
- German
- ISSN :
- 0044-409X
- Volume :
- 127
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zentralblatt fur Chirurgie
- Publication Type :
- Academic Journal
- Accession number :
- 11935479
- Full Text :
- https://doi.org/10.1055/s-2002-24252