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Patterns of mitosis in hamster epidermis.

Authors :
Mackenzie IC
Zimmerman KL
Wheelock DA
Source :
The American journal of anatomy [Am J Anat] 1975 Dec; Vol. 144 (4), pp. 461-6.
Publication Year :
1975

Abstract

Alignment of the flattened keratinizing cells of the upper strata of mammalian epidermis leads to the formation of columnar units of structure. In mouse epidermis, mitoses have been found to occur relatively infrequently in the region beneath the center of each cell column where a non-keratinocyte dendritic cell, usually with freatures typical of an epidermal Langerhans cell, is situated. The observed pattern of mitosis could therefore be due either to displacement of central keratinocytes by Langerhans cells or indicate some control of keratinocyte proliferation related either to the Langerhans cells or to the over-lying cell columns. No relationship exists between the position of Langerhans cells and epidermal cell columns in hamster epidermis but measurement of the position of mitosis has shown a reduced frequency of occurrence of mitosis beneath the central region. This pattern of mitosis is therefore unrelated to Langerhans cells and appears to reflect differences in the mitotic potential of basal keratinocytes which could be associated with feedback from the overlying cell columns or with an intrinsic pattern of basal cell activity.

Details

Language :
English
ISSN :
0002-9106
Volume :
144
Issue :
4
Database :
MEDLINE
Journal :
The American journal of anatomy
Publication Type :
Academic Journal
Accession number :
1199961
Full Text :
https://doi.org/10.1002/aja.1001440406