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Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities. A randomized, double-blind, placebo-controlled trial.
- Source :
-
Annals of internal medicine [Ann Intern Med] 2002 May 21; Vol. 136 (10), pp. 742-6. - Publication Year :
- 2002
-
Abstract
- Background: Many elderly female residents of long-term care facilities have osteoporosis and could benefit from intervention to increase bone density.<br />Objective: To examine the efficacy and safety of alendronate for treatment of osteoporosis in elderly female residents of long-term care facilities.<br />Design: Multicenter, randomized, double-blind, placebo-controlled 2-year study.<br />Setting: 25 long-term care facilities.<br />Patients: 327 elderly women with osteoporosis.<br />Intervention: Patients were randomly assigned to receive alendronate, 10 mg/d, or placebo. All patients also received vitamin D, 400 IU/d, and some patients received supplemental calcium (total intake, approximately 1500 mg/d).<br />Measurements: Bone mineral density (BMD) of the spine and hip and biochemical markers of bone turnover.<br />Results: Alendronate produced significantly greater increases in BMD than did placebo (24-month differences: spine, 4.4% [95% CI, 3.3% to 5.5%]; femoral neck, 3.4% [CI, 2.3% to 4.4%]). Alendronate produced greater decreases from baseline in biochemical markers of bone turnover than did placebo (P < 0.001).<br />Conclusion: Alendronate increased BMD at both the spine and hip in elderly female residents of long-term care facilities.
- Subjects :
- Aged
Aged, 80 and over
Calcium therapeutic use
Dietary Supplements
Double-Blind Method
Female
Humans
Osteoporosis, Postmenopausal metabolism
Vitamin D therapeutic use
Alendronate therapeutic use
Bone Density drug effects
Long-Term Care
Osteoporosis, Postmenopausal drug therapy
Residential Facilities
Subjects
Details
- Language :
- English
- ISSN :
- 1539-3704
- Volume :
- 136
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Annals of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12020142
- Full Text :
- https://doi.org/10.7326/0003-4819-136-10-200205210-00009