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[Linkage analysis of cytokine and cytokine-related receptor gene loci and essential hypertension in Chinese].
- Source :
-
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2002 Jun; Vol. 19 (3), pp. 221-4. - Publication Year :
- 2002
-
Abstract
- Objective: To investigate the genetic linkage between several cytokine and cytokine-related receptor gene loci and essential hypertension (EH) in Chinese.<br />Methods: Linkage between seven genetic markers and EH in 95 Chinese nuclear families with EH (including 477 subjects) was analyzed using a technique of fluorescence-based gene scan with DNA short tandem repeat loci. These markers were selected from the chromosomal regions nearby eight cytokines and their receptor genes. The two-point non-parametric linkage analysis (NPL), maximum Lod score and transmission/disequilibrium test (TDT) with GENEHUNTER software package were used in this study.<br />Results: Result of TDT showed significant transmission disequilibrium between D14S61 and EH (Chi square 14.29,P=0.00016) although NPL and Lod score revealed no significant linkage (Z=0.78, P>0.05 and Lod score =0.72 respectively) at this locus. No linkage between other loci typed and EH was found by the three genetic analysis methods (P>0.05 or Lod score<-1).<br />Conclusion: Alleles at D14S61 were of significant transmission disequilibrium in affected siblings. Transforming growth factor beta 3 is 0.1 cM away from D14S61, which suggests that the relationship between genes at or near this regions and EH needs to be further explored.
- Subjects :
- Adult
Alleles
Blood Glucose metabolism
Blood Pressure physiology
Body Mass Index
China
Cholesterol blood
Cholesterol, HDL blood
Cholesterol, LDL blood
DNA genetics
Family Health
Female
Genetic Linkage
Humans
Hypertension blood
Hypertension physiopathology
Linkage Disequilibrium
Lod Score
Male
Microsatellite Repeats
Middle Aged
Triglycerides blood
Cytokines genetics
Hypertension genetics
Receptors, Cytokine genetics
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-9406
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 12048683