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CTLA-4: new insights into its biological function and use in tumor immunotherapy.
- Source :
-
Nature immunology [Nat Immunol] 2002 Jul; Vol. 3 (7), pp. 611-8. - Publication Year :
- 2002
-
Abstract
- The discovery of multiple costimulatory cell surface molecules that influence the course of T cell activation has increased our appreciation of the complexity of the T cell response. It remains clear, however, that CD28 and cytotoxic T lymphocyte antigen 4 (CTLA-4) are the critical costimulatory receptors that determine the early outcome of stimulation through the T cell antigen receptor (TCR). Details of how the T cell integrates TCR stimulation with the costimulatory signals of CD28 and the inhibitory signals of CTLA-4 remain to be established, but unique features of the cell biology of CTLA-4 provide important insights into its function. We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses. We also describe preclinical and clinical results that indicate manipulation of CTLA-4 has considerable promise as a strategy for the immunotherapy of cancer.
- Subjects :
- Abatacept
Animals
Antigens, CD
Antigens, Differentiation genetics
Antigens, Differentiation therapeutic use
CTLA-4 Antigen
Cell Division
Colonic Neoplasms therapy
Disease Models, Animal
Fibrosarcoma therapy
Gene Expression Regulation
Humans
Lymphocyte Activation
Mice
Neoplasms immunology
T-Lymphocytes immunology
Antigens, Differentiation immunology
Immunoconjugates
Immunotherapy methods
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2908
- Volume :
- 3
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12087419
- Full Text :
- https://doi.org/10.1038/ni0702-611