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Electrophoretic, immunologic and kinetic characterization of erythrocyte pyruvate kinase in the Basenji dog with pyruvate kinase deficiency.
- Source :
-
The Tohoku journal of experimental medicine [Tohoku J Exp Med] 1975 Oct; Vol. 117 (2), pp. 179-85. - Publication Year :
- 1975
-
Abstract
- The electrophoretic mobility and the immunologic specificity of erythrocyte pyruvate kinase (PK) of the homozygous Basenji dog with PK deficiency were identical to those of normal M2-type PK isozyme seen in the white cell but not to those of the erythrocyte PK isozyme. Kinetic properties and stability were also consistent with the M2-type PK isozyme. Defective PK in the homozygous red cell was due to the absence of the erythrocyte PK isozyme and the compensatory presence of M2-type PK isozyme, as seen in the severe classical type PK deficiency in man.
- Subjects :
- Animals
Dogs
Electrophoresis, Polyacrylamide Gel
Heterozygote
Homozygote
Immune Sera
Liver enzymology
Muscles enzymology
Pyruvate Kinase immunology
Pyruvate Kinase isolation & purification
Spleen enzymology
Disease Models, Animal
Dog Diseases enzymology
Erythrocytes enzymology
Pyruvate Kinase deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 0040-8727
- Volume :
- 117
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Tohoku journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 1209607
- Full Text :
- https://doi.org/10.1620/tjem.117.179