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A comparison of paroxetine and amisulpride in the treatment of dysthymic disorder.
- Source :
-
Journal of affective disorders [J Affect Disord] 2002 Aug; Vol. 70 (3), pp. 313-7. - Publication Year :
- 2002
-
Abstract
- Background: The purpose of this study was to provide preliminary data on the effects of paroxetine and amisulpride on depressive dimensions, analyzed by factor analysis, in dysthymic patients.<br />Methods: One hundred and eighteen patients with DSM IV criteria for DD without concurrent major depression were enrolled in this 8-week, open study, and 100 completed it. Symptom dimensions were identified by principal components analysis with the SAS Factor procedure.<br />Results: Results of the symptom rating scales indicated that both drugs were equally effective. Response rate was 65% both in the paroxetine and the amisulpride group and the proportions of patients achieving a final HRSD score < or =7 were 46.7 and 55%, respectively. MADRS factor analysis identified two factors at baseline: the first corresponding to the global severity of depression and the second to somatic symptoms. After 8 weeks of treatment only one factor could be substantiated. At week 4 both paroxetine and amisulpride produced significant improvements on factor 1 while at week 8 mean changes of factor 1 were greater in the amisulpride-treated patients.<br />Limitations: The main limitation was the open-label design.<br />Conclusions: Both paroxetine and amisulpride appear to be effective in the short-term management of DD, improving its most characteristic symptoms.<br /> (Copright 2002 Elsevier Science BV.)
- Subjects :
- Administration, Oral
Adult
Amisulpride
Antidepressive Agents, Second-Generation administration & dosage
Antipsychotic Agents administration & dosage
Drug Therapy, Combination
Dysthymic Disorder psychology
Female
Humans
Male
Middle Aged
Sulpiride administration & dosage
Treatment Outcome
Antidepressive Agents, Second-Generation pharmacology
Antipsychotic Agents pharmacology
Dysthymic Disorder drug therapy
Sulpiride analogs & derivatives
Sulpiride pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-0327
- Volume :
- 70
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 12128243
- Full Text :
- https://doi.org/10.1016/s0165-0327(01)00327-5