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Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.
- Source :
-
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2002 Aug 15; Vol. 404 (2), pp. 234-42. - Publication Year :
- 2002
-
Abstract
- A second female-predominant murine CYP3A, CYP3A44, was isolated from liver and its mRNA expression was compared with that of the previously described CYP3A41. The expression of CYP3A44 was relatively constant after birth in females, whereas it gradually declined in males after 5 weeks of age. The expression of CYP3A41 increased with age in females after 3 weeks of age, whereas it gradually declined in males after 5 weeks of age. Hypophysectomy and growth hormone replacement indicated that expression of both CYP3A mRNAs in females was dependent on the feminine plasma growth hormone profile. Estradiol induced the expression of both mRNAs and the effect was dependent on the presence of the pituitary gland. These observations suggest that endocrine control of expression might be similar, but not identical, for two female-predominant CYP3A mRNAs.<br /> (Copyright 2002 Elsevier Science (USA).)
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Castration
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System metabolism
DNA, Complementary genetics
DNA, Complementary isolation & purification
Estradiol pharmacology
Female
Gene Expression drug effects
Growth Hormone pharmacology
Hypophysectomy
Hypothalamo-Hypophyseal System physiology
Liver drug effects
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Organ Specificity
Ovariectomy
Oxidoreductases metabolism
Oxidoreductases, N-Demethylating metabolism
Sex Factors
Testosterone pharmacology
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 Enzyme System genetics
Gene Expression Regulation, Developmental physiology
Liver enzymology
Oxidoreductases genetics
Oxidoreductases, N-Demethylating genetics
RNA, Messenger metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9861
- Volume :
- 404
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Archives of biochemistry and biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 12147261
- Full Text :
- https://doi.org/10.1016/s0003-9861(02)00329-6