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Oxaliplatin loaded PLAGA microspheres: design of specific release profiles.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2002 Aug 21; Vol. 242 (1-2), pp. 243-6. - Publication Year :
- 2002
-
Abstract
- Oxaliplatin loaded PLAGA microspheres have been prepared by solvent extraction process. Parameters affecting the release kinetics in vitro have been studied in order to design specific release profiles suitable for direct intra-tumoral injection. By varying the nature and the relative proportions of different polymers we managed to prepare microspheres with good encapsulation efficiency (75-90%) and four different release profiles: zero order kinetics (type II) and the classical sigmoïd release profile with three different sizes of plateau and burst. These results, if correlated with in vivo activity, are promising to enhance effectiveness of local tumor treatment.
- Subjects :
- Delayed-Action Preparations
Drug Compounding
Excipients
Kinetics
Microscopy, Electron, Scanning
Microspheres
Oxaliplatin
Particle Size
Polylactic Acid-Polyglycolic Acid Copolymer
Solubility
Antineoplastic Agents administration & dosage
Lactic Acid chemistry
Organoplatinum Compounds administration & dosage
Polyglycolic Acid chemistry
Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0378-5173
- Volume :
- 242
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 12176255
- Full Text :
- https://doi.org/10.1016/s0378-5173(02)00166-7