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Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2002 Sep; Vol. 46 (9), pp. 3031-4. - Publication Year :
- 2002
-
Abstract
- In 2000, at the Université d'Auvergne teaching hospital in Clermont-Ferrand, France, 44 (6.2%) strains of Pseudomonas aeruginosa were found to be resistant to ceftazidime. After genotyping, 34 strains were selected. Nine had an additional beta-lactamase: OXA-21 (n = 6), PSE-1 (CARB-2) (n = 2), or PER-1 (n = 1). Ceftazidime resistance was related solely to the overproduction of the cephalosporinase in 30 strains. Sequencing of five bla(AmpC) genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1.
- Subjects :
- Ceftazidime therapeutic use
Cephalosporinase genetics
Cephalosporinase metabolism
Cephalosporins therapeutic use
Data Collection
Drug Resistance, Microbial
France epidemiology
Genes, Bacterial
Genotype
Humans
Microbial Sensitivity Tests
Prospective Studies
beta-Lactamase Inhibitors
beta-Lactamases genetics
Ceftazidime pharmacology
Cephalosporins pharmacology
Pseudomonas Infections epidemiology
Pseudomonas Infections microbiology
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa enzymology
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 46
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 12183264
- Full Text :
- https://doi.org/10.1128/AAC.46.9.3031-3034.2002