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Buprenorphine dosing regime in the management of out-patient heroin withdrawal.
- Source :
-
Drug and alcohol review [Drug Alcohol Rev] 2002 Mar; Vol. 21 (1), pp. 39-45. - Publication Year :
- 2002
-
Abstract
- This study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutex tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were 6.1 (1.2) mg on day 1; 9.6 (1.7) mg on day 2; 10.1 (1.9) mg on day 3; 8.9 (2.0) mg on day 4; 4.1 (1.5) mg on day 5; and a total regime dose of 38.9 (5.8) mg. Withdrawal severity was mild, with minimal rebound upon the cessation of dosing. Five subjects reported no heroin use, and five subjects reported using on only one occasion during the 8 days. An out-patient buprenorphine regime is recommended.
- Subjects :
- Adult
Ambulatory Care statistics & numerical data
Buprenorphine adverse effects
Drug Administration Schedule
Female
Heroin Dependence psychology
Humans
Male
Patient Satisfaction statistics & numerical data
Severity of Illness Index
Substance Withdrawal Syndrome psychology
Ambulatory Care methods
Buprenorphine administration & dosage
Heroin Dependence drug therapy
Substance Withdrawal Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0959-5236
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug and alcohol review
- Publication Type :
- Academic Journal
- Accession number :
- 12189003
- Full Text :
- https://doi.org/10.1080/09595230220119309