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Androgen receptor CAG polymorphism and prostate cancer risk.
Androgen receptor CAG polymorphism and prostate cancer risk.
- Source :
-
Human genetics [Hum Genet] 2002 Aug; Vol. 111 (2), pp. 166-71. Date of Electronic Publication: 2002 Jul 03. - Publication Year :
- 2002
-
Abstract
- Recent studies have suggested that polymorphisms of the androgen receptor gene ( AR) may influence the risk of prostate cancer (PC) development and progression. Here, we analyzed the length of the CAG repeat of the AR gene in 1363 individuals, including patients with PC, benign prostate hyperplasia (BPH), and population controls. There was a tendency for short CAG repeats to be associated with PC. The Odds Ratio (OR) for PC was 1.47 ( P=0.05) when individuals with short CAG repeats (</=18) were compared with those having long repeats (>18). CAG repeat length was not significantly associated with family history, disease stage, grade, age at diagnosis, prostate-specific antigen (PSA) level at diagnosis, or prognosis of the patients. Unexpectedly, short CAG repeats were significantly less common in patients with BPH compared with controls (OR=0.47, P=0.03). Our results suggest that the CAG polymorphism of the AR gene is unlikely to have a major role in the development or progression of PC in the Finnish population. The association of CAG repeats with the risk of BPH warrants further study.
- Subjects :
- Aged
Aged, 80 and over
Case-Control Studies
DNA, Neoplasm analysis
Disease-Free Survival
Humans
Male
Middle Aged
Neoplasm Recurrence, Local genetics
Neoplasm Staging
Polymerase Chain Reaction
Prostatic Hyperplasia genetics
Risk Factors
Polymorphism, Genetic
Prostatic Neoplasms genetics
Receptors, Androgen genetics
Trinucleotide Repeats genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0340-6717
- Volume :
- 111
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 12189490
- Full Text :
- https://doi.org/10.1007/s00439-002-0776-5