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Amine-related neurotoxins in Parkinson's disease: past, present, and future.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 2002 Sep-Oct; Vol. 24 (5), pp. 565-9. - Publication Year :
- 2002
-
Abstract
- Parkinson's disease (PD) is an aging-related movement disorder caused by a deficiency of the neurotransmitter dopamine (DA) in the striatum of the brain as a result of selective degeneration of nigrostriatal DA neurons. The molecular basis of the cell death of DA neurons is unknown, but one hypothesis is the presence of some amine-related neurotoxins that kill specifically nigrostriatal DA neurons over a long period of time. This neurotoxin hypothesis of PD started in the 1980s when 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was discovered to produce acutely PD-like symptoms. Two groups of natural MPTP-like and amine-related neurotoxins have been investigated as endogenous candidate compounds: isoquinolines (IQs) and beta-carbolines. These neurotoxins are speculated to cause oxidative stress, mitochondrial dysfunction, apoptotic cell death, and PD symptoms. However, since PD is a neurodegenerative disorder that progresses slowly over a period of many years, a long-term study may be required to elucidate the neurotoxicity of such neurotoxins in relation to PD.
- Subjects :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs & derivatives
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine chemistry
Amines chemistry
Animals
Apoptosis drug effects
Apoptosis physiology
Carbolines chemistry
Carbolines toxicity
Humans
Isoquinolines chemistry
Isoquinolines toxicity
Neostriatum pathology
Neostriatum physiopathology
Neurons metabolism
Neurons pathology
Neurotoxins chemistry
Parkinson Disease metabolism
Parkinson Disease physiopathology
Substantia Nigra pathology
Substantia Nigra physiopathology
Amines toxicity
Neostriatum drug effects
Neurons drug effects
Neurotoxins toxicity
Parkinson Disease, Secondary chemically induced
Substantia Nigra drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0892-0362
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 12200187
- Full Text :
- https://doi.org/10.1016/s0892-0362(02)00209-x