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Borna Disease Virus--reactive antibodies in Polish psychiatric patients.

Authors :
Rybakowski F
Sawada T
Yamaguchi K
Rajewski A
Rybakowski J
Source :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2002 Sep; Vol. 8 (9), pp. CR642-6.
Publication Year :
2002

Abstract

Background: It has been proposed that the Borna Disease Virus (BDV) plays a role in the etiopathogenesis of psychiatric disorders. We assessed BDV seropositivity in Polish psychiatric patients and healthy controls, and the relationship between seropositivity and selected diagnostic and clinical variables.<br />Material/methods: Serum samples from 946 psychiatric patients with different diagnoses (ICD-10) and 407 psychiatrically healthy controls were assayed. The ECLIA method was used, which enables the assessment of two anti-BDV antibodies: anti-p24 and anti p-40. Data were also collected on diagnosis, age, age at onset, and place of residence.<br />Results: Only anti-p24 antibodies were found. The seropositivity rates were: 2.4% and 1.0%, respectively, in patients and controls (p=0.1). A significant difference between patients and controls was observed in mental retardation and affective-anxiety spectrum disorders. Seropositivity did not show any association with demographic variables, but it was elevated in patients with recent onset of disease vs. remote onset of disease (10.2% vs. 1.6%; p=0.0003).<br />Conclusions: Significantly higher anti-BDV seropositivity was found in Polish psychiatric patients with affective-anxiety spectrum disorders and mental retardation than in controls. The association between recent onset disorders and higher anti-BDV response, in the light of recent reports on circulating immune complexes of BDV antigens and antibodies, warrants further studies on the longitudinal course of humoral response to BDV.

Details

Language :
English
ISSN :
1234-1010
Volume :
8
Issue :
9
Database :
MEDLINE
Journal :
Medical science monitor : international medical journal of experimental and clinical research
Publication Type :
Academic Journal
Accession number :
12218946