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The evaluation of graft irradiation as a method of preventing hemolysis after ABO-mismatched renal transplantation.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2002 Sep; Vol. 15 (8), pp. 421-4. Date of Electronic Publication: 2002 Jul 26. - Publication Year :
- 2002
-
Abstract
- Hemolysis may occur after organ transplantation. In most cases, hemolysis is drug-related, such as to cyclosporin, etc. However, it is important to consider graft-versus-host antibody formation as one of the causes of hemolysis. We evaluated the effect of local graft irradiation as a method of preventing hemolysis arising from ABO antibody formation after ABO-mismatched renal transplantations. The participants in this study were 44 patients who had undergone ABO-mismatched renal transplantation. Of these patients, 23 were subjected to postoperative local irradiation, and 21 were not. We examined the characteristics of anti-blood-type antibodies, and we also compared the frequency of the development of antibody formation and hemolysis development between the groups. The development rates of anti-ABO-antibody formation and hemolysis were significantly higher in the patients without local irradiation (15/21, 71%; 6/21, 29%) than in those with local irradiation (1/23, 4%; 0/23, 0%). The elevated antibodies mainly belonged to the IgG class, not the IgM class. The hemolysis- and antibody formation observed in the patients originally without postoperative local irradiation was dramatically improved by graft irradiation. Local graft irradiation after ABO-mismatched renal transplantations may be needed to prevent the formation of anti-ABO antibodies and to impede the development of hemolysis.
Details
- Language :
- English
- ISSN :
- 0934-0874
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 12221462
- Full Text :
- https://doi.org/10.1007/s00147-002-0442-9