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Atorvastatin reduces plasma levels of factor VII activity and factor VII antigen in patients with hyperlipidemia.
- Source :
-
Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2002; Vol. 9 (1), pp. 72-7. - Publication Year :
- 2002
-
Abstract
- Atorvastatin is a powerful new synthetic 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor currently in clinical use. Its effects on plasma levels of factor VII were examined in 30 hyperlipidemic patients. After 12 weeks of atorvastatin treatment, factor VII activity (FVIIc) and factor VII antigen (FVIIag) levels had decreased by 13% (p < 0.0001) and 12% (p < 0.0001), respectively. The decreased concentrations of serum triglycerides correlated with decreases in FVIIc levels (r = 0.54, p = 0.0023) and FVIIag levels (r = 0.59, p = 0.0006) at 12 weeks of treatment with atorvastatin. No significant changes were seen in activated factor VII (FVIIa) levels. Plasma concentrations of fibrinogen were slightly, but not significantly, increased at 12 weeks. No significant changes were seen in plasminogen activator inhibitor-1 levels. The effects of atorvastatin on FVII may contribute to a decreased thrombotic potential, resulting in fewer thromboembolic events, including a reduction in coronary heart disease.
- Subjects :
- Aged
Atorvastatin
Blood Glucose
Female
Fibrinogen metabolism
Hemostasis drug effects
Humans
Hyperlipidemias epidemiology
Hyperlipidemias metabolism
Isoantigens blood
Male
Middle Aged
Risk Factors
Thrombosis epidemiology
Thrombosis prevention & control
Triglycerides blood
Anticholesteremic Agents administration & dosage
Antigens metabolism
Factor VII metabolism
Heptanoic Acids administration & dosage
Hyperlipidemias drug therapy
Pyrroles administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1340-3478
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of atherosclerosis and thrombosis
- Publication Type :
- Academic Journal
- Accession number :
- 12238641
- Full Text :
- https://doi.org/10.5551/jat.9.72