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Low-dose dexamethasone reduces nausea and vomiting after tympanomastoid surgery: a comparison of tropisetron with saline.
- Source :
-
American journal of otolaryngology [Am J Otolaryngol] 2002 Sep-Oct; Vol. 23 (5), pp. 267-71. - Publication Year :
- 2002
-
Abstract
- Purpose: The aim of the study was to evaluate the efficacy of low-dose dexamethasone sodium phosphate (5 mg) on the prophylaxis of nausea and vomiting after tympanomastoid surgery. Tropisetron hydrochloride (2 mg) and saline were used as controls.<br />Materials and Methods: One hundred twenty patients (n = 40 in each of 3 groups) undergoing general anesthesia for tympanomastoid surgery were enrolled in this randomized, double-blind, placebo-controlled study. Following endotracheal intubation, group 1 received intravenous dexamethasone 5 mg, whereas groups 2 and 3 received intravenous 2 mg tropisetron and saline, respectively. Several parameters connected with the occurrence of postoperative nausea and vomiting were evaluated.<br />Results: Dexamethasone 5 mg significantly reduced the total incidence of nausea and vomiting by 40% (P =.002). Dexamethasone also reduced the incidence of vomiting episodes by more than 4-fold (P =.03) and the incidence of patients requiring rescue antiemetics (P =.02). Tropisetron at a 2-mg dose did not exhibit any significant antiemetic effect.<br />Conclusions: Dexamethasone sodium phosphate 5 mg was more effective than 2 mg tropisetron hydrochloride and saline in the prevention of nausea and vomiting after tympanomastoid surgery.<br /> (Copyright 2002, Elsevier Science (USA). All rights reserved.))
- Subjects :
- Adult
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Injections, Intravenous
Male
Middle Aged
Tropisetron
Antiemetics administration & dosage
Antiemetics therapeutic use
Dexamethasone administration & dosage
Dexamethasone therapeutic use
Indoles therapeutic use
Mastoid surgery
Postoperative Nausea and Vomiting prevention & control
Tympanoplasty adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0196-0709
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of otolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 12239690
- Full Text :
- https://doi.org/10.1053/ajot.2002.126319