Back to Search
Start Over
Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2002 Oct 15; Vol. 186 (8), pp. 1173-6. Date of Electronic Publication: 2002 Sep 20. - Publication Year :
- 2002
-
Abstract
- Secretory leukocyte protease inhibitor (SLPI), a protein found in saliva, breast milk, and genital secretions, is capable of inhibiting human immunodeficiency virus (HIV) type 1 in vitro. The aim of this study was to determine whether SLPI in infant saliva provides protection against mother-to-child HIV-1 transmission. In total, 602 saliva specimens were collected from 188 infants at birth and at ages 1, 3, and 6 months. Infants' median salivary SLPI concentrations were higher at birth than at 6 months (341 vs. 219 ng/mL; P=.001). There was no association between SLPI concentration and HIV-1 transmission overall. However, among 122 breast-fed infants who were HIV-1 uninfected at 1 month, higher salivary SLPI levels were associated with a decreased risk of HIV-1 transmission through breast milk (hazard ratio, 0.5; 95% confidence interval, 0.3-0.9; P=.03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk.
- Subjects :
- Anti-HIV Agents analysis
Anti-HIV Agents metabolism
Female
Humans
Infant
Infant, Newborn
Pregnancy
Proteinase Inhibitory Proteins, Secretory
Proteins analysis
Risk Factors
Secretory Leukocyte Peptidase Inhibitor
Disease Susceptibility
HIV Infections transmission
HIV-1 physiology
Infectious Disease Transmission, Vertical
Milk, Human virology
Proteins metabolism
Saliva chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 186
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 12355371
- Full Text :
- https://doi.org/10.1086/343805