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[High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City].
- Source :
-
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion [Rev Invest Clin] 2002 Jul-Aug; Vol. 54 (4), pp. 299-306. - Publication Year :
- 2002
-
Abstract
- Objective: To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City.<br />Material and Methods: Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done.<br />Results: One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree.<br />Conclusions: The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer.
- Subjects :
- Adult
Biopsy
Case-Control Studies
DNA Probes, HPV
DNA, Viral isolation & purification
Female
Hospitals, General
Hospitals, Public
Humans
Mexico epidemiology
Middle Aged
Nucleic Acid Hybridization
Papillomaviridae classification
Papillomaviridae pathogenicity
Prevalence
Prospective Studies
Reproductive History
Risk Factors
Surveys and Questionnaires
Urban Population
Uterine Cervical Dysplasia epidemiology
Uterine Cervical Dysplasia virology
Uterine Cervical Dysplasia pathology
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Neoplasms pathology
Virulence
Papillomaviridae isolation & purification
Papillomavirus Infections epidemiology
Uterine Cervical Neoplasms virology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0034-8376
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
- Publication Type :
- Academic Journal
- Accession number :
- 12415953