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Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder.
- Source :
-
Neuropsychobiology [Neuropsychobiology] 2002; Vol. 46 (3), pp. 136-40. - Publication Year :
- 2002
-
Abstract
- Genetic polymorphism of the serotonin 5-HT(2A) receptor seems to be associated with therapeutic response to selective serotonin reuptake inhibitors (SSRIs). The present study investigated whether a novel -1438G/A polymorphism in the promoter region of the 5-HT(2A )receptor gene is associated with therapeutic response to fluvoxamine (an SSRI) in 66 Japanese patients with major depressive disorder. Fluvoxamine (50 to 200 mg) was administered twice daily for 6 weeks. Fifty-four patients completed this study. The genotype distribution and the allele frequencies showed no significant difference between responders and non-responders. The time-course of the Montgomery-Asberg Depression Rating Scale scores showed no significant difference among -1438G/G, -1438G/A, and -1438A/A genotype groups. The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.<br /> (Copyright 2002 S. Karger AG, Basel)
- Subjects :
- Adult
Aged
Chi-Square Distribution
Depressive Disorder, Major genetics
Dose-Response Relationship, Drug
Female
Fluvoxamine blood
Gene Frequency
Genotype
Humans
Japan
Male
Middle Aged
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Receptor, Serotonin, 5-HT2A
Selective Serotonin Reuptake Inhibitors blood
Time Factors
Treatment Outcome
Depressive Disorder, Major drug therapy
Fluvoxamine therapeutic use
Promoter Regions, Genetic genetics
Receptors, Serotonin genetics
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0302-282X
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuropsychobiology
- Publication Type :
- Academic Journal
- Accession number :
- 12422060
- Full Text :
- https://doi.org/10.1159/000066394