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Neurotrophin-3 is required for appropriate establishment of thalamocortical connections.
- Source :
-
Neuron [Neuron] 2002 Nov 14; Vol. 36 (4), pp. 623-34. - Publication Year :
- 2002
-
Abstract
- In the vertebrate brain, the thalamus serves as a relay and integration station for diverse neuronal information en route from the periphery to the cortex. Formation of the thalamocortical tract occurs during pre- and postnatal development, with distinct thalamic nuclei projecting to specific cortical regions. The molecular forces that underlie the invasion by axons into specific cortical layers followed by activity-dependent maturation of synapses are poorly understood. We show that genetic ablation of neurotrophin-3 (NT-3) in the mouse neocortex results in reduction of a set of anatomically distinct axonal bundles projecting from thalamus through cortical white matter. These bundles include thalamocortical axons that normally establish connections with retrosplenial and visual cortex, sites of early postnatal NT-3 expression. These results implicate neurotrophins in the critical stage of precise thalamocortical connections.
- Subjects :
- Animals
Animals, Newborn
Cell Communication genetics
Cerebral Cortex cytology
Cerebral Cortex metabolism
Chemotaxis genetics
DNA-Binding Proteins genetics
Forkhead Transcription Factors
Gene Expression Regulation, Developmental genetics
Growth Cones ultrastructure
Integrases genetics
Mice
Mice, Knockout
Mutation genetics
Nerve Fibers, Myelinated metabolism
Nerve Fibers, Myelinated pathology
Nerve Tissue Proteins genetics
Neural Pathways cytology
Neural Pathways metabolism
Neurotrophin 3 genetics
Thalamus cytology
Thalamus metabolism
Viral Proteins genetics
Vision Disorders genetics
Vision Disorders metabolism
Vision Disorders physiopathology
Visual Cortex abnormalities
Visual Cortex cytology
Visual Cortex metabolism
Cell Differentiation genetics
Cerebral Cortex abnormalities
Growth Cones metabolism
Neural Pathways abnormalities
Neurotrophin 3 deficiency
Thalamus abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 12441052
- Full Text :
- https://doi.org/10.1016/s0896-6273(02)01021-8