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Evidence for heterogeneity of T cell expansion in polymyositis and inclusion body myositis.

Authors :
van der Meulen MF
van Wichen DF
van Blokland WT
van den Berg LH
Wokke JH
Hoogendijk JE
de Weger RA
Source :
Journal of neuroimmunology [J Neuroimmunol] 2002 Dec; Vol. 133 (1-2), pp. 198-204.
Publication Year :
2002

Abstract

Vbeta usage of muscle-infiltrating T lymphocytes in polymyositis (PM) and sporadic inclusion body myositis (s-IBM) was correlated with clinical and histopathological features. Immunohistochemical analysis was combined with complementarity-determining region 3 (CDR3) length analysis in nine muscle biopsies of eight PM patients and six biopsies of five s-IBM patients. Vbeta usage was heterogeneous in seven patients. Four of these patients had definite PM with endomysial located T cell infiltrates, but T cells specifically surrounding and invading individual non-necrotic fibers were not found. In two s-IBM patients, Vbeta 2 usage was increased. In one of them, a repeat biopsy showed a heterogeneous Vbeta usage. We conclude that clonal expansion of muscle-infiltrating T cells could only be detected in part of the patients. Explanations may be that clonal expansion does not take place in all disease phases and that PM is a heterogeneous disease with respect to pathogenesis.

Details

Language :
English
ISSN :
0165-5728
Volume :
133
Issue :
1-2
Database :
MEDLINE
Journal :
Journal of neuroimmunology
Publication Type :
Academic Journal
Accession number :
12446023
Full Text :
https://doi.org/10.1016/s0165-5728(02)00363-6