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Extensor digitorum brevis test and resistance to botulinum toxin type A.
- Source :
-
Muscle & nerve [Muscle Nerve] 2002 Dec; Vol. 26 (6), pp. 828-31. - Publication Year :
- 2002
-
Abstract
- We studied 22 patients with dystonia to determine the normal range of values for the extensor digitorum brevis (EDB) test, and to determine its sensitivity and specificity in detecting resistance to botulinum toxin type A (BTX-A). Three compound muscle action potentials (CMAPs) elicited by peroneal nerve stimulation were averaged before and 2 weeks after injection of 20 units of BTX-A into the EDB. Amplitude and area ratios were calculated by dividing the averaged postinjection CMAP by the averaged preinjection CMAP values. The difference in means of this ratio between clinically sensitive and resistant subjects was statistically significant (P < 0.002). A normal range of <0.45 for each ratio was determined by adding two standard deviations to the ratio mean of 14 clinically sensitive subjects. Four of five resistant patients had values outside the normal range. The EDB test is a simple quantitative method of detecting resistance to BTX-A, with a sensitivity of 80% and specificity of 94%.<br /> (Copyright 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 828-831, 2002)
- Subjects :
- Action Potentials physiology
Adult
Aged
Aged, 80 and over
Dystonic Disorders physiopathology
Electrophysiology
Humans
Middle Aged
Muscle Contraction physiology
Muscle, Skeletal innervation
Muscle, Skeletal physiology
Predictive Value of Tests
Action Potentials drug effects
Botulinum Toxins, Type A pharmacology
Drug Resistance physiology
Dystonic Disorders drug therapy
Muscle Contraction drug effects
Muscle, Skeletal drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0148-639X
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 12451609
- Full Text :
- https://doi.org/10.1002/mus.10231