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Replication-defective genomic herpes simplex vectors: design and production.
- Source :
-
Current opinion in biotechnology [Curr Opin Biotechnol] 2002 Oct; Vol. 13 (5), pp. 424-8. - Publication Year :
- 2002
-
Abstract
- Herpes simplex virus (HSV) may be engineered to produce flexible and efficient gene delivery vectors. Recent advances in vector design and production have built on increasing understanding of the basic biology of HSV to minimise vector toxicity and exploit viral features that give rise to lifelong latent infection in the nervous system. In addition, the emerging picture of viral cell entry has allowed early steps to be taken towards targeting viral entry to predetermined cellular subsets. Recent work has established sound principles for the straightforward production of large-scale pure preparations of vector stocks for clinical applications.
- Subjects :
- DNA, Recombinant genetics
DNA, Recombinant therapeutic use
Defective Viruses genetics
Defective Viruses isolation & purification
Gene Expression Regulation, Viral
Genetic Therapy methods
Genetic Vectors therapeutic use
Humans
Neoplasms therapy
Recombination, Genetic
Virus Replication genetics
Gene Transfer Techniques
Genetic Vectors genetics
Genetic Vectors isolation & purification
Genome, Viral
Herpesvirus 1, Human genetics
Herpesvirus 1, Human isolation & purification
Nervous System Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0958-1669
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current opinion in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 12459332
- Full Text :
- https://doi.org/10.1016/s0958-1669(02)00359-2