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Transformation of trichothecenes in ileal digesta and faeces from pigs.
- Source :
-
Archiv fur Tierernahrung [Arch Tierernahr] 2002 Aug; Vol. 56 (4), pp. 263-74. - Publication Year :
- 2002
-
Abstract
- The capacity of pig gastrointestinal microflora to metabolise the trichothecenes 3-acetyl-deoxynivalenol (3-acDON) and nivalenol (NIV) was investigated. 3-acDON was deacetylated to DON in anaerobic incubations with pig faeces collected at different pig farms. Furthermore, both 3-acDON and NIV were metabolised to the corresponding deepoxy metabolite in these incubates. Five pigs, in which the gastrointestinal microflora lacked the ability to transform 3-acDON and NIV to their corresponding de-epoxidated metabolites, were given low levels of DON in the feed for seven weeks. The gastrointestinal micro-organisms did not acquire the de-epoxidation ability during the seven week long exposure period. At the end of the exposure period, faeces from pigs with a known de-epoxidation ability was spread out in the pens and left for 24 hours. One week after the faeces had been spread out in the pens, the de-epoxidation ability was found in faecal incubations from four out of five experimental pigs. This change in metabolic ability of the intestinal de-epoxidation ability was not accompanied by any detectable changes in the DNA-profiles of the bacterial community composition. The results show that the intestinal de-epoxidation ability is common at pig farms in the Uppsala area, and that the ability may be transferred between pigs in a stock.
- Subjects :
- Animal Feed
Animals
Biotransformation
Chromatography veterinary
DNA, Bacterial analysis
Feces chemistry
Food Contamination
Gastrointestinal Contents chemistry
Gastrointestinal Contents microbiology
Ileum chemistry
Ileum metabolism
Male
Specific Pathogen-Free Organisms
Trichothecenes analysis
Feces microbiology
Ileum microbiology
Swine metabolism
Trichothecenes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0003-942X
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archiv fur Tierernahrung
- Publication Type :
- Academic Journal
- Accession number :
- 12462911
- Full Text :
- https://doi.org/10.1080/00039420214343