Back to Search
Start Over
Hepatic hemangioendothelioma: hemodynamic observations and treatment.
- Source :
-
Pediatrics [Pediatrics] 1976 Jan; Vol. 57 (1), pp. 131-5. - Publication Year :
- 1976
-
Abstract
- The clinical course of five infants with heptic hemangioendothelioma is reviewed. Hemodynamic abnormalities observed at cardiac catheterization included an increased cardiac output (range, 9.2 to 10.5 liters/min/sq m) with over 50% of this output being shunted through the arteriovenous malformation, an elevated right and left end diastolic pressure (8 to 10 mm Hg and 9 to 15 mm Hg respectively), a small systolic pressure gradient across the pulmonary outflow tract (4 to 6 mm Hg), and mild elevation of pulmonary artery pressure (range, 35/16 to 37/12 mm Hg). All four patients treated with prednisone improved while on therapy; three are well one to three years after cessation of therapy. One patient died from unrecognized congestive heart failure following discontinuation of prednisone and another before prednisone was started. We conclude that prednisone in high doses (2 to 4 mg/kg/day) with the addition of digitalis and diuretics for control of congestive heart failure is an effective treatment regimen for infants with hepatic hemangioendothelioma.
- Subjects :
- Blood Pressure
Cardiac Catheterization
Cardiac Output
Female
Hemangioendothelioma blood
Hemangioendothelioma drug therapy
Humans
Infant
Infant, Newborn
Liver Neoplasms blood
Liver Neoplasms drug therapy
Male
Oxygen blood
Prednisone therapeutic use
Pulmonary Circulation
Hemangioendothelioma physiopathology
Hemodynamics
Liver Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0031-4005
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 1246488