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The skeletal site-differential changes in bone mineral density following bone marrow transplantation: 3-year prospective study.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2002 Dec; Vol. 17 (6), pp. 749-54. - Publication Year :
- 2002
-
Abstract
- Loss of bone mass is usually detected after bone marrow transplantation (BMT) during the early post-transplant period. However, little is known about the long-term effects of BMT on bone metabolism. We have prospectively investigated 11 patients undergoing BMT. Bone mineral density (BMD) was measured before BMT, and 1, 2, and 3 yr after BMT. Serum markers of bone turnover were serially measured before BMT and 1, 2, 3, 4, and 12 weeks, 6 months, and 1 yr after BMT. The mean change in the lumbar spine (L2-4) BMD, calculated as the percent change from the baseline to the level at 1, 2, and 3 yr was -4.7% (NS), -1.1% (NS), and +6.4% (p<0.05), respectively. The mean change in the total proximal femur BMD from the baseline to the level at 1, 2, and 3 yr was -8.5% (p<0.01), -8.7% (p<0.05) and -5.6% (p<0.05), respectively. In summary, there was little decline in lumbar BMD at 1 yr following BMT and gradual recovery until 3 yr. In contrast, femoral BMD decreased much more than the lumbar area at 1 yr and did not recover until 3 yr. The mechanism of skeletal site-selective differences in the changes of BMD needs to be elucidated.
- Subjects :
- Adult
Age Factors
Anemia, Aplastic therapy
Bone Marrow Transplantation
Bone and Bones drug effects
Bone and Bones radiation effects
Collagen blood
Collagen Type I
Cyclophosphamide therapeutic use
Estradiol blood
Follicle Stimulating Hormone blood
Humans
Leukemia therapy
Luteinizing Hormone blood
Middle Aged
Myelodysplastic Syndromes therapy
Peptides blood
Prospective Studies
Time Factors
Bone Density
Bone and Bones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1011-8934
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 12482996
- Full Text :
- https://doi.org/10.3346/jkms.2002.17.6.749