Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: the development of a highly potent prodrug.

Subjects

Subjects :

Animals
Bronchial Neoplasms drug therapy
Bronchial Neoplasms pathology
Carcinoma, Pancreatic Ductal drug therapy
Carcinoma, Pancreatic Ductal pathology
Cell Division drug effects
Cyclopropanes administration & dosage
Cyclopropanes chemistry
Female
Galactosides chemistry
Humans
Immunoconjugates administration & dosage
Indoles administration & dosage
Indoles chemistry
Inhibitory Concentration 50
Male
Mice
Mice, SCID
Prodrugs administration & dosage
Prodrugs therapeutic use
Prodrugs toxicity
Tumor Cells, Cultured
beta-Galactosidase
Cyclopropanes therapeutic use
Enzyme Therapy
Immunoconjugates therapeutic use
Indoles therapeutic use
Neoplasms drug therapy

Details

Language :

English

ISSN :

1433-7851

Volume :

41

Issue :

5

Database :

MEDLINE

Journal :

Angewandte Chemie (International ed. in English)

Publication Type :

Academic Journal

Accession number :

12491327

Full Text :

https://doi.org/10.1002/1521-3773(20020301)41:5<759::aid-anie759>3.0.co;2-7