Back to Search Start Over

Selenoamino acids in tissues of rats administered inorganic selenium.

Authors :
Olson OE
Palmer IS
Source :
Metabolism: clinical and experimental [Metabolism] 1976 Mar; Vol. 25 (3), pp. 299-306.
Publication Year :
1976

Abstract

There are conflicting reports in the literature concerning the synthesis of selenoamino acids from inorganic selenium in animals, and this work was undertaken to further investigate this. Pronase digests of acetone powders of liver and kidney tissue from rats administered 75SeO3= were subjected to fractionation by cation exchange chromatography using current methods for separating the various amino acids. Very little, if any, selenocystine was found in the digests. However, good evidence was obtained for the occurrence of 2,7-diamino-4-thia-5-selenaoctanedioic acid. It is suggested that the selenocysteine portion of this compound was formed by the reduction of the selenite to selenide with its subsequent incorporation into the amino acid by the action of serine hydrolase (E C 4.2.1.22). No selenomethionine was found under the conditions of this study.

Details

Language :
English
ISSN :
0026-0495
Volume :
25
Issue :
3
Database :
MEDLINE
Journal :
Metabolism: clinical and experimental
Publication Type :
Academic Journal
Accession number :
1250164
Full Text :
https://doi.org/10.1016/0026-0495(76)90087-1