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Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2002 Dec; Vol. 26 (7-8), pp. 1279-83. - Publication Year :
- 2002
-
Abstract
- Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). The genetic polymorphisms of these two enzymes might individually alter the production, release, reuptake or degradation of 5-HT during the treatment of selective serotonin reuptake inhibitors (SSRIs), leading to the individual differences in the antidepressant effects of SSRIs. The authors investigated whether a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and a TPH gene polymorphism in intron 7 (TPH-A218C) were associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder during a 6-week study with a specific dosage plan. Fifty-four patients completed the study. The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder.
- Subjects :
- Adult
Aged
Depressive Disorder psychology
Female
Humans
Japan
Male
Middle Aged
Promoter Regions, Genetic genetics
Treatment Outcome
Antidepressive Agents, Second-Generation pharmacology
Depressive Disorder drug therapy
Depressive Disorder genetics
Fluvoxamine pharmacology
Monoamine Oxidase genetics
Monoamine Oxidase pharmacology
Polymorphism, Genetic
Tryptophan Hydroxylase genetics
Tryptophan Hydroxylase pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0278-5846
- Volume :
- 26
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 12502014
- Full Text :
- https://doi.org/10.1016/s0278-5846(02)00267-1