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Factors affecting antibody levels after allogeneic hematopoietic cell transplantation.
- Source :
-
Blood [Blood] 2003 Apr 15; Vol. 101 (8), pp. 3319-24. Date of Electronic Publication: 2002 Dec 27. - Publication Year :
- 2003
-
Abstract
- To obtain insight into the mechanism(s) of posttransplantation humoral immunodeficiency, we evaluated factors affecting serum antibody levels against polio, tetanus, Haemophilus influenzae, and Streptococcus pneumoniae in 87 patients. Patients with hematologic malignancies were randomized to receive marrow versus blood stem cells, which contain approximately 10 times more lymphocytes than marrow. Blood stem cell recipients did not have higher antibody levels than marrow recipients. Recipient pretransplantation antibody levels were correlated with the posttransplantation levels, especially in the first 6 months after transplantation when the correlation coefficients typically exceeded 0.6. Donor pretransplantation antibody levels had less of a correlation with posttransplantation levels in the recipient. Patient or donor age, total body irradiation, and graft-versus-host disease or its treatment appeared to have no effect. In conclusion, antibody levels in the first year after transplantation are affected primarily by pretransplantation antibody levels in the recipient and, to a lesser degree, in the donor. These findings suggest that immunization of the recipient and the donor before transplantation may be more effective in improving antibody immunity after transplantation than manipulating graft-versus-host disease, changing conditioning, or increasing the number of lymphocytes in the graft.
- Subjects :
- Adult
Aged
Antibody Specificity
Antigens, Bacterial immunology
Antigens, Viral immunology
Female
Follow-Up Studies
Graft vs Host Disease immunology
Humans
Immunoglobulin G blood
Immunologic Memory
Immunosuppression Therapy adverse effects
Male
Middle Aged
Randomized Controlled Trials as Topic
Tissue Donors
Transplantation Conditioning
Whole-Body Irradiation adverse effects
Antibody Formation radiation effects
Bone Marrow Transplantation immunology
Peripheral Blood Stem Cell Transplantation
Transplantation, Homologous immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 101
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 12506030
- Full Text :
- https://doi.org/10.1182/blood-2002-05-1376