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The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2003 Feb 01; Vol. 170 (3), pp. 1197-201. - Publication Year :
- 2003
-
Abstract
- IL-12 is a potent cytokine that impairs the growth of several tumors in vivo in natural as well as in therapeutic conditions. Although IL-12 can enhance a number of immunological antitumor mechanisms, including those mediated by NK cells and CTL, recent reports have suggested that the mouse CD1d-restricted V alpha 14-J alpha 18 NKT cell was the essential cell type recruited in most, if not all tumor rejection models, including the B16 melanoma. In this study, we have examined and compared the role of NKT cells, T cells, NK cells, and other non-T non-B cells in the rejection of B16 melanoma cells after exogenous administration of IL-12. Surprisingly, our results failed to confirm a necessary role for NKT cells in this model. Instead, we found that NK cells mediated the rejection of liver metastases, whereas other gamma c-dependent non-T non-B cells, possibly lymphoid dendritic cells, were required for rejection of skin tumors. These findings challenge the view that NKT cells are systematically required for IL-12-mediated rejection of tumors, and instead reveal that a variety of effector pathways can be recruited depending on the tumor microenvironment.
- Subjects :
- Animals
B-Lymphocyte Subsets immunology
Drug Administration Schedule
Graft Rejection genetics
Injections, Intralesional
Injections, Intraperitoneal
Injections, Intravenous
Injections, Subcutaneous
Interleukin Receptor Common gamma Subunit
Interleukin-12 administration & dosage
Interleukin-12 therapeutic use
Lymphocyte Activation immunology
Lymphocyte Depletion
Melanoma, Experimental genetics
Melanoma, Experimental immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Tumor Cells, Cultured
Antineoplastic Agents administration & dosage
Antineoplastic Agents therapeutic use
Graft Rejection immunology
Interleukin-12 physiology
Killer Cells, Natural immunology
Melanoma, Experimental prevention & control
Receptors, Interleukin-7 physiology
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 170
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 12538676
- Full Text :
- https://doi.org/10.4049/jimmunol.170.3.1197