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Sequential high-dose chemotherapy with autologous stem cell support in patients with limited-stage small cell lung cancer.
- Source :
-
Anticancer research [Anticancer Res] 2002 Nov-Dec; Vol. 22 (6B), pp. 3723-6. - Publication Year :
- 2002
-
Abstract
- To determine the feasibility and safety of multiple sequential courses of high-dose chemotherapy with peripheral blood progenitor cells (PBSCs) followed by thoracic irradiation (54 Gy) and prophylactic cranial irradiation (PCI 30 Gy) in patients with limited disease (LD) small cell lung cancer (SCLC), six patients received one cycle of conventional-dose chemotherapy followed by four cycles of high-dose chemotherapy with stem cell support. Neither significant adverse side-effects nor treatment mortality were observed. CR and almost CR (> 90%) was obtained in five out of six patients while one patient had a partial response (PR). The median survival was 21.3 months (range 8-34). However, the benefit of the high CR rate and prolonged survival did not result in cure even in these favorable circumstances, because all the patients died of recurrence in the cerebral nervous system. According to our data we stopped this chemotherapy regime because it was not able to prevent cerebral disease.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols adverse effects
Brain Neoplasms prevention & control
Brain Neoplasms secondary
Carboplatin administration & dosage
Carboplatin adverse effects
Carcinoma, Small Cell pathology
Carcinoma, Small Cell radiotherapy
Carcinoma, Small Cell therapy
Combined Modality Therapy
Cranial Irradiation
Cyclophosphamide administration & dosage
Cyclophosphamide adverse effects
Dose-Response Relationship, Drug
Epirubicin administration & dosage
Epirubicin adverse effects
Etoposide administration & dosage
Etoposide adverse effects
Granulocyte Colony-Stimulating Factor administration & dosage
Hematopoietic Stem Cell Mobilization
Humans
Ifosfamide administration & dosage
Ifosfamide adverse effects
Lung Neoplasms pathology
Lung Neoplasms radiotherapy
Lung Neoplasms therapy
Male
Middle Aged
Neoplasm Staging
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Small Cell drug therapy
Lung Neoplasms drug therapy
Peripheral Blood Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 22
- Issue :
- 6B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 12552983