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Absence of D- alloimmunization in AIDS patients receiving D-mismatched RBCs.

Authors :
Boctor FN
Ali NM
Mohandas K
Uehlinger J
Source :
Transfusion [Transfusion] 2003 Feb; Vol. 43 (2), pp. 173-6.
Publication Year :
2003

Abstract

Background: More than 80 percent of D- patients who receive D+ blood become alloimmunized to the D antigen. Anemia occurs in most AIDS patients at some point in the disease. D- patients with AIDS may require blood transfusion and, during times of blood shortage, may receive D+ RBCs. They would be expected to become alloimmunized to the d antigen.<br />Study Design and Methods: The records of the transfusion service between January 1996 and July 2000 were reviewed for D- patients who received D+ blood. IATs were performed before the initial transfusion and subsequently when the patient required further RBC transfusion.<br />Results: Eight D- AIDS patients who received multiple transfusions (three women and five men; age range, 31-44 years; mean, 44 years) who received between 2 and 11 units (mean, 6.25) of D+ RBCs were identified. Antibody screens were performed at 8 to 65 weeks after transfusion. It was found that none of the eight D- AIDS patients developed anti-D. ABO antibodies were found as expected. During the same period, it was found that six D- patients admitted with other diagnoses who received 1 to 9 units of D+ RBCs, all developed anti-D within 7 to 19 weeks of transfusion.<br />Conclusion: Patients with AIDS may not form alloantibodies to the D antigen. This may be attributable to their immunodepressed state, particularly to the decrease in CD4+ T lymphocytes. Therefore, during blood shortages, transfusion of D+ blood to D- AIDS patients may be without any subsequent consequence.

Details

Language :
English
ISSN :
0041-1132
Volume :
43
Issue :
2
Database :
MEDLINE
Journal :
Transfusion
Publication Type :
Academic Journal
Accession number :
12559012
Full Text :
https://doi.org/10.1046/j.1537-2995.2003.00289.x