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Synthesis of labelled PNA oligomers by a post-synthetic modification approach.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Feb 10; Vol. 13 (3), pp. 391-3. - Publication Year :
- 2003
-
Abstract
- The preparation of t-butoxycarbonyl (Boc)-protected O(4)-(o-nitrophenyl) thymine peptide nucleic acid (PNA) monomer is described. This PNA monomer was incorporated into PNA oligomer sequences. The post-synthetic modification of the oligomers to yield fluorescently-labelled PNA oligomers was studied before and after the removal of the protecting groups. In both cases, the desired fluorescently-labelled PNA oligomer was obtained in good yields.
- Subjects :
- Fluorescent Dyes chemical synthesis
Indicators and Reagents
Nitro Compounds chemistry
Oligonucleotides chemistry
Peptide Nucleic Acids chemistry
Formic Acid Esters chemical synthesis
Nitro Compounds chemical synthesis
Oligonucleotides chemical synthesis
Peptide Nucleic Acids chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 12565936
- Full Text :
- https://doi.org/10.1016/s0960-894x(02)00994-0