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[Role of beta-adrenoceptor antagonists in the control of kindling models in rats].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2000 Dec; Vol. 35 (12), pp. 886-9. - Publication Year :
- 2000
-
Abstract
- Aim: To study the role of beta-adrenoceptors (beta-AR) and their subtypes in the control of kindling models in rats.<br />Methods: Electrical amygdala kindling, pentylenetetrazol (PTZ) kindling models in rats and maximal electroshock (MES) in mice were used to observe the effects of beta-AR agonists and antagonists.<br />Results: The beta-AR antagonist propranolol 15 mg.kg-1 i.p. delayed the development of amygdala kindling; while propranolol 1-20 mg.kg-1 i.p. and beta-AR antagonist metoprolol 25-400 mg.kg-1 ig significantly increased the afterdischarge threshold and reduced the seizure severity in both kindling models (P < 0.01). beta 1-AR agonist dobutamine completely reversed the inhibitory effect of propranolol, while the beta 2-AR agonist terbutaline showed no effect on propranolol. Metoprolol 200 and 800 mg.kg-1 ig significantly inhibited MES in mice (P < 0.01).<br />Conclusion: Central beta 1-AR is involved in the inhibitory effects on amygdala kindling and PTZ kindling models in rats.
- Subjects :
- Adrenergic beta-1 Receptor Antagonists
Animals
Anti-Anxiety Agents pharmacology
Female
Kindling, Neurologic physiology
Male
Metoprolol pharmacology
Mice
Rats
Rats, Wistar
Receptors, Adrenergic, beta-1 physiology
Adrenergic beta-Antagonists pharmacology
Kindling, Neurologic drug effects
Propranolol pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 35
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 12567907