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Epidemiology of multiple organ dysfunction syndrome in critical surgical illness.

Authors :
Barie PS
Hydo LJ
Source :
Surgical infections [Surg Infect (Larchmt)] 2000 Fall; Vol. 1 (3), pp. 173-85; discussion 185-6.
Publication Year :
2000

Abstract

Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in surgical intensive care units (SICUs). Multiple organ dysfunction syndrome remains the most important factor associated with mortality in the SICU. Illness severity scores such as the Acute Physiology and Chronic Health Evaluation-III (APACHE III) and the magnitude of the systemic inflammatory response syndrome (SIRS) at the time of SICU admission are useful in stratifying patients at risk for MODS and subsequent mortality. Assessment of key organ systems shows that mortality correlates with the overall severity of organ dysfunction and the number of involved organ systems, as well as to individual organs that fail. Despite the prognostic utility of SIRS/MODS, definitions of dysfunction of individual organs have shortcomings. The problem with quantitating MODS lies in the inability to adequately define organ dysfunction, especially of the gastrointestinal tract, liver, and central nervous system. Biological indicators of organ dysfunction may prove to be better markers for MODS in the future.

Details

Language :
English
ISSN :
1096-2964
Volume :
1
Issue :
3
Database :
MEDLINE
Journal :
Surgical infections
Publication Type :
Academic Journal
Accession number :
12594888
Full Text :
https://doi.org/10.1089/109629600750018105