Back to Search
Start Over
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
- Source :
-
Current opinion in cell biology [Curr Opin Cell Biol] 2003 Apr; Vol. 15 (2), pp. 241-6. - Publication Year :
- 2003
-
Abstract
- Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
Details
- Language :
- English
- ISSN :
- 0955-0674
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 12648681
- Full Text :
- https://doi.org/10.1016/s0955-0674(03)00006-1