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The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2003 Apr 01; Vol. 17 (7), pp. 965-73. - Publication Year :
- 2003
-
Abstract
- Background: The acid suppressive effect of lansoprazole is influenced by the P450 2C19 (CYP2C19) polymorphism.<br />Aim: To investigate whether the CYP2C19 genotype is related to the healing of erosive reflux oesophagitis during treatment with lansoprazole.<br />Methods: Eighty-eight Japanese patients with erosive reflux oesophagitis were treated with a daily oral dose of 30 mg lansoprazole for 8 weeks. The CYP2C19 genotype, Helicobacter pylori infection status and serum pepsinogen I/II ratio were assessed before treatment. At 4 and 8 weeks, the healing of erosive reflux oesophagitis was evaluated endoscopically.<br />Results: The healing rates were 57.1%, 69.2% and 72.7% at 4 weeks and 77.4%, 95.0% and 100% at 8 weeks in homozygous extensive metabolizers, heterozygous extensive metabolizers and poor metabolizers, respectively. At 8 weeks, the healing rate of erosive reflux oesophagitis was significantly lower in homozygous extensive metabolizers than in the other two groups (P < 0.05). The H. pylori status and serum pepsinogen I/II ratio had less influence than CYP2C19 polymorphism on the healing rate of erosive reflux oesophagitis.<br />Conclusions: The therapeutic effect of lansoprazole on erosive reflux oesophagitis is influenced by the CYP2C19 genotype status. Therefore, a test of CYP2C19 genotype may be useful for the medical treatment of reflux oesophagitis with lansoprazole.
- Subjects :
- 2-Pyridinylmethylsulfinylbenzimidazoles
Esophagitis, Peptic genetics
Female
Gastroesophageal Reflux genetics
Humans
Lansoprazole
Male
Middle Aged
Omeprazole analogs & derivatives
Treatment Outcome
Anti-Ulcer Agents therapeutic use
Cytochrome P-450 Enzyme System
Esophagitis, Peptic drug therapy
Gastroesophageal Reflux drug therapy
Omeprazole therapeutic use
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0269-2813
- Volume :
- 17
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 12656699
- Full Text :
- https://doi.org/10.1046/j.1365-2036.2003.01539.x